PGF challenge test in asthma and chronic bronchitis


A. Lahdensuo, Ounasrinne Hospital, Kolpeneentie 21, SF-96440 Rovaniemi 44, Finland.


PGF2SaL challenge tests were performed in twenty-three patients with bronchial asthma and six patients with chronic bronchitis; two patients with allergic rhinitis and four healthy volunteers also participated in the trial. FEV1 measurements were used in assessing the reactions. PGE challenge proved safe and practical in clinical use. A wide scattering in PGF reactivity was seen, but sensitivity to PGF did not correlate to several clinical criteria. Comparison with an ordinary histamine challenge revealed that the sensitivity of the patients to PGF and histamine was not uniform.