A comparative trial of intra-nasal beclomethasone dipropionate and sodium cromoglycate in patients with chronic perennial rhinitis


Associate Professor J. D. Wilson, Department of Medicine, University of Auckland, Private Bag, Auckland, New Zealand.


A double-blind crossover study has compared intra-nasal sodium cromoglycate (SCG) with beclomethasone dipropionate (BDP), and both drugs with placebo, in fifty-two chronic perennial rhinitis patients, BDP was significantly more effective in relieving symptoms than SCG (76.9% and 50% of the patients improved respectively, P<0.01). Both drugs were more active than placebos but while BDP was very clearly more effective (P<0.0005) SCG was only marginally better than its placebo (P<0.05, Fisher; P=0.068, χ2). BDP was selected by 56% of the patients as the best agent for continuing therapy at the end of the trial. By contrast SCG was preferred by the same number of patients as chose the two placebos (11.5%).