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The in vitro effect of levamisole on lymphocyte proliferation, polymorphonuclear leucocyte chemotaxis, basophil histamine release and platelet serotonin release in patients with atopic dermatitis

Authors

  • R. D. O'CONNOR,

    1. Pediatric Immunology and Allergy Division, Department of Pediatrics, University of California, San Diego and Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California
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  • J. RING,

    1. Pediatric Immunology and Allergy Division, Department of Pediatrics, University of California, San Diego and Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California
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  • A. A. JALOWAYSKI,

    1. Pediatric Immunology and Allergy Division, Department of Pediatrics, University of California, San Diego and Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California
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  • R. N. HAMBURGER

    Corresponding author
    1. Pediatric Immunology and Allergy Division, Department of Pediatrics, University of California, San Diego and Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California
      Dr Robert N. Hamburger, University of California, San Diego, Department of Pediatrics M-009D, Immunology and Allergy Division, La Jolla, California 92093, U.S.A.
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Dr Robert N. Hamburger, University of California, San Diego, Department of Pediatrics M-009D, Immunology and Allergy Division, La Jolla, California 92093, U.S.A.

Summary

The in vitro effect of levamisole (LMS) on lymphocyte, neutrophil, basophil and platelet function was investigated in patients with severe atopic dermatitis and hyper-immunoglobulinaemia E. Lymphocyte stimulation by several concentrations of PHA, con A and PWM, polymorphonuclear leukocyte chemotaxis and basophil histamine release were unaffected by LMS (10 μg/ml). Platelet serotonin release induced by iodipamide was decreased in patient and control groups by LMS but release induced by methacholine, epinephrine and thrombin was not.

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