An open comparison of dosage frequencies of beclomethasone dipropionate in seasonal allergic rhinitis


Dr Niels Mygind. Otopathological Laboratory. University of Copenhagen. Rigshospitalet. DK-2100 Copenhagen, Denmark


In an open group-comparative study, 123 adult patients with seasonal allergic rhinitis were allocated at random to one of three treatment groups; each of which received a daily dose of 400 μg beclomethasone dipropionate as (1) one puff in each nostril four times daily, (2) two puffs in each nostril twice daily and (3) four puffs in each nostril once per day. The result of treatment was assessed on daily symptom scores and the use of antihistamine tablets. There were no statistically significant differences between the three groups. The results indicate that it is unnecessary to give beclomethasone dipropionate nasal spray four times daily, and treatment in the morning and in the evening is recommended.