Ketotifen and bronchial hyperreactivity in asthmatic patients


Dr J. P. Girard. Division of Immunology and Allergy. Department of Medicine. Geneva University Medical School. Hôpital Cantonal, Geneva. Switzerland.


The degree of bronchoconstriction after acetylcholine challenge in twenty patients with extrinsic asthma was diminished significantly after 3 months' treatment with 1 mg ketotifen b.i.d. Since ketotifen has no appreciable anticholinergic effect this observation is an indication that ketotifen decreases the non-specific bronchial hyperreactivity when administered over 3 months.