Staphylococcal and human dander IgE antibodies in superinfected atopic dermatitis
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 12, Issue 2, pages 113–120, March 1982
How to Cite
HENOCQ, E., HEWITT, B. and GUERIN, B. (1982), Staphylococcal and human dander IgE antibodies in superinfected atopic dermatitis. Clinical & Experimental Allergy, 12: 113–120. doi: 10.1111/j.1365-2222.1982.tb01629.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 14 March 1981; accepted for publication 24 April 1981)
Ten patients (Group 1) with Staphylococcus aureus superinfected atopic dermatitis (SAD) were compared with three control groups without SAD. One control group (Group 2) was comprised of ten atopic patients with total IgE levels of > 1000 u/ml, another control group, of six atopic patients (Group 3) with total IgE levels of < 1000. u/ml and a third group, often non-atopics (Group 4), five of whom were infected with Staphylococcus aureus. Total and specific anti-staphylococcal IgE levels and anti-human dander IgE were high in Group 1. Specific IgE levels to S. aureus were slightly increased in some Group 2 patients but were normal (< 7%) for Group 3. No specific IgE to human dander antigen was detected in either Group 2 or Group 3.
In the non-atopic control group (Group 4), six out of ten patients had both low total, and specific IgE antibodies to both Staphylococcal, and human dander antigens. Two had increased total IgE and specific anti-staphylococcal IgE antibodies, and two more with a severe, chronic infection, also had anti-staphylococcal IgE antibodies.
In SAD patients, a good correlation was seen between cutaneous basophil hypersensitivity and high specific IgE antibodies against Staphylococcal and human dander allergens. Delayed type hypersensitivity reactions to Staphylococcal antigen were negative or poorly positive in the SAD group by comparison to controls.
A paradoxical anaphylactic type of response to the offending bacterial agent in SAD patients, associated with ‘auto-atopy’ to human dander, is discussed.