Get access
Clinical & Experimental Allergy

HLA-A, B, C and HLA-DR antigens in extrinsic allergic alveolitis (budgerigar fancier's lung disease)

Authors

  • M. F. MUERS,

    Corresponding author
    1. Department of Chest Medicine, Churchill Hospital, and the Nuffield Department of Surgery, John Radcliffe Hospital, Oxford
      Dr Martin Muers, Consultant Physician, Killingbeck Hospital, York Road, Leeds LS14
    Search for more papers by this author
  • J. A. FAUX,

    1. Department of Chest Medicine, Churchill Hospital, and the Nuffield Department of Surgery, John Radcliffe Hospital, Oxford
    Search for more papers by this author
  • A. TING,

    1. Department of Chest Medicine, Churchill Hospital, and the Nuffield Department of Surgery, John Radcliffe Hospital, Oxford
    Search for more papers by this author
  • P. J. MORRIS

    1. Department of Chest Medicine, Churchill Hospital, and the Nuffield Department of Surgery, John Radcliffe Hospital, Oxford
    Search for more papers by this author

Dr Martin Muers, Consultant Physician, Killingbeck Hospital, York Road, Leeds LS14

Summary

Twenty-three patients with extrinsic allergic alveolitis due to an allergy to inhaled budgerigar serum protein (budgerigar fancier's lung disease) were typed for HLA-A, B, C and HLA-DR antigens. Antigen frequencies were compared with those found in 154 healthy control subjects. No statistically significant variation in the frequency of any HLA antigen was detected. Exclusion of two patients who had concurrent coeliac disease, and subdivision of the population into those with acute and chronic disease, failed to reveal any significant association with an HLA specificity. A non-significant increase in B8-DR3 amongst the patients with acute disease was noted. Possible reasons for the apparent HLA associations previously reported by others for extrinsic allergic alveolitis are discussed.

Get access to the full text of this article

Ancillary