A woman developed generalized symptoms of hypersensitivity when she was stung requiring treatment with adrenalin.
Intradermal venom skin tests showed immediate hypersensitivity to yellow hornet and white-faced hornet thus fulfilling the criteria to receive appropriate venom immunotherapy.
During the course of modified rush immunotherapy with yellow hornet and white-faced hornet venoms, she developed transient but progressive bradycardia necessitating interruption of the venom immunotherapy. Transient bradycardia recurred when venom immunotherapy was resumed but it was possible to reach a maintenance dose of 100 mg protein for each venom.
Bradycardia has been reported to be induced in experimental animals by oriental hornet venom as well as other venoms, through a direct cholinergic action. It appears that a similar effect may occur in man in susceptible individuals during venom immunotherapy.
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