Latent anaphylactic sensitivity of infants to cow's milk proteins

Histamine release from blood basophils


Dr P. McLaughlan, Division of Immunology, Department of Pathology, Laboratories Block, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ.


Approximately 25% of infants tested released >9% of their blood basophil histamine content in the presence of cow's milk proteins, indicating a degree or level of latent anaphylactic sensitivity to these allergens. Approximately 10% of infants show a considerably higher level of sensitivity (14-63% histamine release). These findings fulfil an essential tenet of the modified anaphylactic hypothesis for cot-death.