Effect of house dust mite on serum complement activation and total haemolytic activity in vitro in normal subjects and in patients with bronchial asthma


Dr L.M. Srivastava, Assistant Professor. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India.


House dust mite (Dermatophagoides farinae) has been shown to activate the complement system in vitro by both the classical and alternative pathways in normal serum and in two groups of (skin test positive and skin test negative) patients with bronchial asthma. The activation was dose dependent in the lower range of allergen concentrations. Skin test positive asthmatic subjects showed the maximum activation. Skin test negative patients had activation between skin test positive patients and normal subjects. However, at the higher allergen concentration normal serum and bronchial asthma patients showed similar results.