A community survey of IgG4 antibody levels


; Dr T.G Merrett, RAST Allergy Unit, Benenden Chest Hospital, C'ranbrook, Kent.


Precise and specific radioimmunoassays have been developed to quantify IgG4 and IgG4 antibodies. A community survey has demonstrated that men have significantly higher total serum lgG4 levels than women: geometric mean values of 0.581 mg/ml versus 0.302 mg/ml. This sex difference was extended to total IgE values. Circulating levels of IgG4 antibodies against foods, especially egg-and milk, were normally higher than those against the three most common U.K. inhalant allergens–grass pollen, house dust mite and cat epithelium,