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Clinical & Experimental Allergy

Plasma histamine concentrations in atopic eczema

Authors

  • J. RING

    Corresponding author
    1. Dermatology Department, Ludwig Maximilians University Munich, West Germany
      Dr Johannes Ring, Dermatologische Universitätsklinik. Frauenlobstraβe 9-11, D-8GOO München 2, West Germany.
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Dr Johannes Ring, Dermatologische Universitätsklinik. Frauenlobstraβe 9-11, D-8GOO München 2, West Germany.

Summary

Plasma histamine concentrations were determined using a radio-enzymatic assay in fifty-four patients suffering from atopic eczema and in thirty-nine controls (contact dermatitis, psoriasis and normal non-alopic healthy volunteers). While in none of the controls histamine levels in plasma exceeded 1 ng/ ml, seventeen out of fifty-four patients with atopic eczema showed increased plasma histamine concentrations ranging between 1-2 and 5′2 ng/ml. Elevated plasma histamine levels were found mostly in patients with severe eczema and high serum IgE. levels. Longitudinal studies in seven patients revealed normal plasma histamine values during clinical remission.

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