Experience with allergic bronchopulmonary aspergillosis: some unusual features
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 14, Issue 1, pages 21–28, January 1984
How to Cite
BRESLIN, A. B. X. and JENKINS, C. R. (1984), Experience with allergic bronchopulmonary aspergillosis: some unusual features. Clinical & Experimental Allergy, 14: 21–28. doi: 10.1111/j.1365-2222.1984.tb02185.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 14 January 1982; accepted for publication 6 December 1982)
The clinical and immunologic features often patients with allergic bronchopulmonary aspergillosis (ABPA), observed over periods varying from 12 months to 10 years, are reported.
Acute attacks of ABPA were characterized by several, or all of: increased cough and sputum, haemoptysis, pleuritic pain, expectoration of sputum plugs, and increasing airways obstruction. Peripheral blood eosinophilia and acutely elevated serum IgE levels were seen in all patients during acute attacks, sputum eosinophilia and recovery of Aspergillus in sputum was less common. However, blood eosinophilia was not present in all attacks of ABPA and sputum eosinophilia varied similarly from one attack to another.
Six patients with previously documented multiple precipitin lines have had no demonstrable precipitins to Aspergillus on several occasions between attacks, three of these patients have also been negative during attacks. Five of the six patients have again developed positive precipitin lines.
The total number of episodes in these ten patients was fifty two, three patients have had more than nine acute attacks of ABPA. There is no seasonal variation in this group of patients. Since diagnosis, only three patients have had an attack-free interval longer than 12 months. Two patients are steroid-dependent because of severe asthma, and nine have symptoms of bronchiectasis.