Modulation by S-adenosyl-methionine and S-adenosyl-homocysteine of the human leucocytes histamine release
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 14, Issue 1, pages 37–43, January 1984
How to Cite
PACHECO, Y., MACOVSCHI, O., BIOT, N., FONLUPT, P., PERRIN-FAYOLLE, M. and PACHECO, H. (1984), Modulation by S-adenosyl-methionine and S-adenosyl-homocysteine of the human leucocytes histamine release. Clinical & Experimental Allergy, 14: 37–43. doi: 10.1111/j.1365-2222.1984.tb02187.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 22 February 1982: accepted for publication 13 December 1982)
Methylation of membrane phospholipids is an important stage in the process of histamine release. This methylation reaction can be modulated by S-adenosyl-methionine (SAM) as well as by S-adenosyl-homocysteine (SAH). The influence of SAM and of SAH upon the histamine release of leucocytes from asthmatic and normal subjects were compared. In concentration of 10-4M, SAM enhanced spontaneous and the specifically induced histamine release. In concentration of 10-5 M SAM enhanced the histamine release only in normals. This phenomenon could indicate a deficit in methyl-transferase activity in the asthamatics.
In concentration of 10-4 M, SAH reduced spontaneous and specifically induced histamine release, having an effect comparable to that of 10-4 M Theophylline.