In vitro investigations in asthmatic children undergoing hyposensitization with tyrosine-adsorbed Dermatophagoides pteronyssinus antigen
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 14, Issue 3, pages 221–231, May 1984
How to Cite
TURNER, M. W., YALCIN, I., SOOTHILL, J. F., PRICE, J. F., WARNER, J.O., HEY, E. N., CHAPMAN, M. D. and PLATTS-MILLS, T. A. E. (1984), In vitro investigations in asthmatic children undergoing hyposensitization with tyrosine-adsorbed Dermatophagoides pteronyssinus antigen. Clinical & Experimental Allergy, 14: 221–231. doi: 10.1111/j.1365-2222.1984.tb02201.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 6 April 1983; accepted for publication 18 April 1983)
Successful hyposensitization to Dermatophagoides pteronyssinus in perennial childhood asthma was associated with a slight mean rise of serum IgG antibody to the mite antigen in contrast to a placebo group in whom this antibody fell slightly. No relationship was detected between the effect on asthma and the magnitude of this change, Nor was there any consistent effect on IgE or IgA antibody.
There was a wide range of total serum IgE and IgE, IgG and IgA antibody to D. pteronyssinus before treatment; this level did not predict the effect of treatment. Some patients lacked IgA antibody.
IgE antibody to timothy grass pollen was raised in some but not others. These levels did not change systematically during the study and improvement occurred in those who had this antibody as well as IgE antibody to D. pteronyssinus.
IgG and IgE antibodies to D. pteronyssinus were significantly correlated in the pre-treatment samples.
Lymphocyte thymidine uptake was lower after 8 weeks of treatment than in the control group, not only after stimulus with D. pteronyssinus antigen, in vitro, but also with antigen from Candida albicans. This was not a serum effect.
The late bronchial provocation response was lost only in those with serum IgA less than the log mean for age.