Xanthippou 99, Holagros, Athens, Greece.
Suppressor T cells and soluble suppressor factors in allergy: effect of immunotherapy
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 14, Issue 6, pages 519–524, November 1984
How to Cite
KESARWALA, H. H., MACCIA, C., AMARAM, N., SZEP, R. and PAPAGEORGIOU, P. (1984), Suppressor T cells and soluble suppressor factors in allergy: effect of immunotherapy. Clinical & Experimental Allergy, 14: 519–524. doi: 10.1111/j.1365-2222.1984.tb02238.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 18 July 1983; accepted for publication 27 July 1983)
Suppressor-cell activity of Concanavalin-A-stimulated lymphocytes was studied in allergic patients by inhibition of one-way mixed lymphocyte culture reactions before and after allergy immunotherapy. This activity was compared with twelve healthy controls. In preliminary experiments, six out of eight allergic patients had no detectable T suppressor activity. In the second prospective group, eight out of eleven patients had much reduced suppressor-cell activity before immunotherapy, and seven out of eleven patients had much reduced activity after immunotherapy. The data suggest that non-specific T suppressor-cell activity is reduced in allergic patients but immunotherapy does not restore such activity.