Suppressor T cells and soluble suppressor factors in allergy: effect of immunotherapy

Authors

  • H. H. KESARWALA,

    Corresponding author
    1. Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Rutgers Medical School, CN19, New Brunswick, New Jersey, U.S.A.
    Search for more papers by this author
  • C. MACCIA,

    1. Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Rutgers Medical School, CN19, New Brunswick, New Jersey, U.S.A.
    Search for more papers by this author
  • N. AMARAM,

    1. Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Rutgers Medical School, CN19, New Brunswick, New Jersey, U.S.A.
    Search for more papers by this author
  • ROSALIA SZEP,

    1. Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Rutgers Medical School, CN19, New Brunswick, New Jersey, U.S.A.
    Search for more papers by this author
  • P. PAPAGEORGIOU

    1. Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Rutgers Medical School, CN19, New Brunswick, New Jersey, U.S.A.
    Search for more papers by this author
    • *

      Xanthippou 99, Holagros, Athens, Greece.


Dr H. H. Kesarwala, Division of Allergy-Immunology, Children's Hospital Medical Center, Elland and Bethesda Avenue, Cincinnati, Ohio 45229, U.S.A.

Summary

Suppressor-cell activity of Concanavalin-A-stimulated lymphocytes was studied in allergic patients by inhibition of one-way mixed lymphocyte culture reactions before and after allergy immunotherapy. This activity was compared with twelve healthy controls. In preliminary experiments, six out of eight allergic patients had no detectable T suppressor activity. In the second prospective group, eight out of eleven patients had much reduced suppressor-cell activity before immunotherapy, and seven out of eleven patients had much reduced activity after immunotherapy. The data suggest that non-specific T suppressor-cell activity is reduced in allergic patients but immunotherapy does not restore such activity.

Ancillary