Aspirin intolerance and asthmal induction of a tolerance and long-term monitoring
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 15, Issue 1, pages 37–42, January 1985
How to Cite
DOR, P. J., VERVLOET, D., BALDOCCHI, G. and CHARPIN, L. (1985), Aspirin intolerance and asthmal induction of a tolerance and long-term monitoring. Clinical & Experimental Allergy, 15: 37–42. doi: 10.1111/j.1365-2222.1985.tb02252.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 5 March 1984; accepted for publication 2 April 1984)
Acetylsalicylic-acid (ASA) intolerance is well recognized as a possible cause for exacerbating asthma. It has been postulated that if this could be overcome, long-term aspirin administration could improve asthma symptoms and enable reduction of the use of other anti-asthmatic drugs.
We succeeded in inducing an ASA tolerance in nine corticosteroid-dependent asthmatics, and this tolerance lasted at least 1 month and at most 1 year. Progressive deterioration in lung function was seen, however, in all patients taking ASA for more than 1 month, unless the corticosteroid intake was increased. These results suggest that ASA long-term treatment is of no help to severe corticosteroid-dependent, ASA-sensitive asthmatics. This conclusion differs from other reports on ASA intolerance in asthma.