Deficient Concanavalin-A-induced suppressor-cell activity in patients with bronchial asthma, allergic rhinitis and atopic dermatitis

Authors

  • KUNG-CHAN HWANG,

    1. Memorial Sloan-Kettering Cancer Center, New York, and Downstate Medical Center, Brooklyn, New York, U.S.A.
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    • *

      Department of Paediatrics, Provincial Tao-Yuan Medical Centre, 1492 Chung-Sun Road, Tao Yuan, Taiwan 330 R.O.C.

  • SENIH M. FIKRIG,

    1. Memorial Sloan-Kettering Cancer Center, New York, and Downstate Medical Center, Brooklyn, New York, U.S.A.
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  • HOWARD M. FRIEDMAN,

    1. Memorial Sloan-Kettering Cancer Center, New York, and Downstate Medical Center, Brooklyn, New York, U.S.A.
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  • SUDHIR GUPTA

    Corresponding author
    1. Memorial Sloan-Kettering Cancer Center, New York, and Downstate Medical Center, Brooklyn, New York, U.S.A.
      Dr Sudhir Gupta, Division of Basic and Clinical Immunology, Department of Medicine, Medical Science I, University of California, Irvine, CA 92717, U.S.A
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Dr Sudhir Gupta, Division of Basic and Clinical Immunology, Department of Medicine, Medical Science I, University of California, Irvine, CA 92717, U.S.A

Summary

Concanavalin-A (Con-A)-induced suppressor activity against the proliferative response of autologous lymphocytes to phytohaemagglutinin (PHA) was examined in the peripheral-blood lymphocytes from fourteen patients with bronchial asthma, ten patients with allergic rhinitis and eleven patients with atopic dermatitis and compared with eleven simultaneously studied healthy normals. Eight of fourteen patients (57%) with bronchial asthma, eight of ten patients (80%) with allergic rhinitis and five of eleven patients (45%) with atopic dermatitis demonstrated deficient Con-A-induced suppressor function. Abnormal suppressor-cell functions could play an important role in the pathogenesis of atopic states.

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