Asthma and urticaria induced by seminal plasma in a woman with IgE antibody and T-lymphocyte responsiveness to a seminal plasma antigen
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 15, Issue 2, pages 117–130, March 1985
How to Cite
BLAIR, H. and PARISH, W. E. (1985), Asthma and urticaria induced by seminal plasma in a woman with IgE antibody and T-lymphocyte responsiveness to a seminal plasma antigen. Clinical & Experimental Allergy, 15: 117–130. doi: 10.1111/j.1365-2222.1985.tb02263.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received 29 April 1983; accepted for publication 20 June 1983; final revision received 1st May 1984)
A patient with asthma urticaria and angioedema induced by allergy to seminal plasma was examined at intervals for 10 years. Before treatment her anaphylactic susceptibility to seminal plasma was manifested by very strong prick-test responses, IgE antibody to an allergenic fraction of seminal plasma determined by RAST, and by antigen-induced histamine release from her blood leucocytes. The skin test and in vitro lymphocyte tests indicated concomitant delayed hypersensitivity to the same allergen. The patient's lymphocytes treated with seminal plasma allergen fraction showed much increased incorporation of thymidine, and also synthesis of a product (NIF) that inhibited migration of neutrophils from a normal donor. The allergen fraction of seminal plasma had about five components in the range of 20000–40000 daltons molecular weight; the major fraction binding IgE appeared to be a glycoprotein.
The patient was successfully desensitized by injections of her husbanďs seminal plasma. Desensitization was not associated with persistent amounts of antigen-specific IgG antibodies.