Awarded the 1985 John Darte Memorial Prize for excellence in pediatric research conducted by residents at the Janeway Child Health Centre, St. John's, Newfoundland, Canada.
Predictive value of cord blood IgE in the development of atopic disease and role of breast-feeding in its prevention
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 15, Issue 6, pages 517–522, November 1985
How to Cite
CHANDRA, R. K., PURI, S. and CHEEMA, P. S. (1985), Predictive value of cord blood IgE in the development of atopic disease and role of breast-feeding in its prevention. Clinical & Experimental Allergy, 15: 517–522. doi: 10.1111/j.1365-2222.1985.tb02304.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received in original form 14 March 1985 and in revised form 4 July 1985; accepted for publication 8 July 1985)
The predictive value of cord blood IgE in the development of atopic disease was evaluated in a prospective study of two groups of infants. Total serum IgE level was ≥ 0.7 U/ml in 44.3% of the infants with positive family history of atopy and in 16.0% among those with negative family history. The level of cord blood IgE correlated significantly with the subsequent development of atopic disease in both groups. Cord blood IgE higher than 0.7 U/ml was associated with a high risk of development of atopic eczema and wheezing, 52.8% and 58.8% respectively in the groups with or without family history of atopy; compared with 13.4% and 1.1% in the groups with IgE levels less than 0.7 U/ml. Among newborns fed exclusively on breast milk for a minimum of 3 months, the incidence of eczema and wheezing was significantly lower (12%) compared with findings in the formula-fed group (32%).