Lymphocyte sub-populations in patients with allergic and non-allergic asthma

Authors

  • JAN KUS,

    1. The Respiratory Division, Department of Medicine, Vancouver General Hospital, University of British Columbia, Canada
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  • KAM S. TSE,

    1. The Respiratory Division, Department of Medicine, Vancouver General Hospital, University of British Columbia, Canada
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  • SVERRE VEDAL,

    1. The Respiratory Division, Department of Medicine, Vancouver General Hospital, University of British Columbia, Canada
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  • MOIRA CHAN-YEUNG

    Corresponding author
    1. The Respiratory Division, Department of Medicine, Vancouver General Hospital, University of British Columbia, Canada
      Dr Moira Chan-Yeung, U.B.C. Department of Medicine, Vancouver General Hospital, 2775 Heather Street, Vancouver, B.C., Canada V5Z 3J5.
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Dr Moira Chan-Yeung, U.B.C. Department of Medicine, Vancouver General Hospital, 2775 Heather Street, Vancouver, B.C., Canada V5Z 3J5.

Summary

The subpopulations of peripheral blood lymphocytes were identified using monoclonal antibodies specific for T lymphocytes (T11 antibodies), B lymphocytes (B1 antibodies), helper/inducer T cells (T4 antibodies) and suppressor/cytotoxic cells (T8 antibodies). Ninety-six subjects, including twenty-five patients with allergic asthma, nineteen patients with non-allergic asthma and fifty-two controls without asthma, were studied. There was no significant difference in the lymphocyte subsets between the allergic and non-allergic asthmatics. When comparing patients with asthma as a group with the controls, a decrease in the number of T8-positive suppressor cells and therefore, an increase in the helper/suppressor cell ratio were demonstrated in the asthamtics. A relative deficiency of suppressor T cells may represent another immunological marker of bronchial asthma.

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