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Double phenotyping of immunoregulatory T cell subsets in patients with allergic asthma
Article first published online: 27 APR 2006
DOI: 10.1111/j.1365-2222.1987.tb02054.x
1365-2222/asset/cover.gif?v=1&s=363d6ac7042b7535760df61b7393fd8e0a08e85f "Clinical & Experimental Allergy")
Additional Information
How to Cite
KOCHMAN, S., BERNARD, J., CAZABAT, A., LAVAUD, F., LORTON, C. and LIEHN, J. C. (1987), Double phenotyping of immunoregulatory T cell subsets in patients with allergic asthma. Clinical & Experimental Allergy, 17: 579–588. doi: 10.1111/j.1365-2222.1987.tb02054.x
Publication History
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Received in original form 23 September 1986 and in second revised form 29 June 1987; accepted for publication 30 June 1987
- Abstract
- References
- Cited By
Summary
In order to determine whether the dissection of helper/inducer (CD4 +) and suppressor/cytotoxic (CD8 +) lymphocyte subsets with Leu 8 reagent would reveal any differences between allergic asthma patients and non-atopic controls, we compared in both groups the ‘true helper’ T cell subset (Leu 8 - CD4 +), responsible for the major helper effect, and one of the suppressor T cell subpopulations (Leu 8 - CD8 +). Peripheral blood mononuclear cells from sixty-nine individuals, including nineteen extrinsic asthmatics, fifteen intrinsic asthmatics, seventeen patients with chronic obstructive lung disease and eighteen healthy controls, were comparatively analysed. Although total CD4 + cells and total CD8 + cells were similar for all groups, we found in the extrinsic asthma patients group a significant increase in the number of ‘true helper’ T cell sublineage (Leu 8 - CD4 +) and of suppressor cells expressing Leu 8 - CD8 + phenotype. Such imbalances may be implicated in the pathogenesis of atopic asthma.