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Clinical manifestations of cows’ milk allergy in childhood. II. The diagnostic value of skin tests and RAST
Article first published online: 27 APR 2006
DOI: 10.1111/j.1365-2222.1988.tb02898.x
1365-2222/asset/cover.gif?v=1&s=363d6ac7042b7535760df61b7393fd8e0a08e85f "Clinical & Experimental Allergy")
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How to Cite
HILL, D. J., DUKE, A. M., HOSKING, C. S. and HUDSON, I. L. (1988), Clinical manifestations of cows’ milk allergy in childhood. II. The diagnostic value of skin tests and RAST. Clinical & Experimental Allergy, 18: 481–490. doi: 10.1111/j.1365-2222.1988.tb02898.x
Publication History
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- (Received in original form 4 January 1988 and in revised form 17 March 1988; accepted for publication 23 March 1988)
- Abstract
- References
- Cited By
Summary
In a study of cows’ milk allergy (CMA) in infancy, 135 consecutive challenges were performed on children with a good clinical history of the disorder. Of these, only half of the patients were shown to have the disease. Highly atopic patients responded rapidly to small volumes of milk with acute urticaria, wheezing, stridor and eczema, whereas patients who were relatively non-atopic developed symptoms of eczema, bronchitis and wheezing over several hours or days. In a statistical evaluation of the diagnostic value of skin tests and RAST it was shown for the extracts used in this investigation, and for the population studied, all patients with SPT 
4 had CMA. The results highlight the potential diagnostic value of SPT in the identification of children with some forms of CMA if standardized cows’ milk allergen extracts can be prepared.