Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 20, Issue 3, pages 269–272, May 1990
How to Cite
HENOCQ, E. and RIHOUX, J.-P. (1990), Does reversed-type anaphylaxis in healthy subjects mimic a real allergic reaction?. Clinical & Experimental Allergy, 20: 269–272. doi: 10.1111/j.1365-2222.1990.tb02682.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 8 June 1989; revised 4 October 1989; accepted 17 November 1989
Immediate and late cutaneous reactions were induced in healthy and atopic subjects by anti-IgE challenge and a skin-window technique was used in order to verify if the pattern of cells observed at 24 hr was similar in both groups. The study was first performed under basal conditions, and in a second double-blind cross-over step, it was performed again during treatment with cetirizine 10 mg b.i.d. and terfenadine 60 mg b.i.d. Anti-IgE challenge was followed by a significant eosinophil accumulation in atopic subjects only. Cetirizine significantly inhibited this phenomenon while terfenadine showed a mild nonsignificant inhibitory effect.