The relationship between anti-IgE auto-antibodies and the IgE response to wasp venom during immunotherapy
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 20, Issue 1, pages 67–69, January 1990
How to Cite
KEMENY, D. M., TOMIOKA, H., TSUTSUMI, A., KOIKE, T., LESSOF, M. H. and LEE, T. H. (1990), The relationship between anti-IgE auto-antibodies and the IgE response to wasp venom during immunotherapy. Clinical & Experimental Allergy, 20: 67–69. doi: 10.1111/j.1365-2222.1990.tb02777.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 12 May 1989; second revision 4 September 1989; accepted 5 September 1989.
During immunotherapy with wasp venom, levels of venom-specific IgE antibodies increase and then fall, whereas the concentration of IgG antibodies rises and then remains at a high level. Successful treatment is therefore associated with both increased concentrations of serum IgG and decreased serum IgE antibodies to venom. In this study we have investigated the possible role of auto-antibodies in inducing the decrease in serum IgE antibody. Levels of auto-anti-IgE were measured by a radioimmunoassay. Anti-IgE auto-antibodies were not generated during immunotherapy and there was no significant difference in the levels of anti-IgE auto-antibodies between patients whose venom-specific IgE antibody levels fell more than fivefold after immunotherapy and those patients in whom IgE antibody levels did not change significantly. We conclude that anti-IgE auto-antibodies do not play a part in IgE suppression induced by immunotherapy.