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Inhibitory effect of inhaled procaterol on anaphylactic bronchoconstriction and thromboxane A2 production in guinea-pigs

Authors

  • M. FUJIMURA,

    Corresponding author
    1. Third Department of Internal Medicine. Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan
      Dr M. Fujimura, Third Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa 920. Japan.
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  • S. SAKAMOTO,

    1. Third Department of Internal Medicine. Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan
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  • K. NISHI,

    1. Third Department of Internal Medicine. Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan
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  • M. SAITO,

    1. Third Department of Internal Medicine. Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan
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  • Y. MIYAKE,

    1. Third Department of Internal Medicine. Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan
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  • T. MATSUDA

    1. Third Department of Internal Medicine. Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa, Japan
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Dr M. Fujimura, Third Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, Kanazawa 920. Japan.

Summary

This study was designed to examine whether an inhaled β2-agonist, procaterol, inhibits thromboxane A2 (TXA2) production induced by antigen challenge in passively sensitized guinea-pigs in vivo. Antigen-induced bronchoconstriction was markedly inhibited by pre-treatment with procaterol. Inhaled procaterol significantly reduced in a dose-dependent manner the increment in TXB2 concentration in bronchoalveolar lavage fluid obtained 5 min after antigen challenge. Aerosol administration of procaterol significantly inhibited bronchoconstriction induced by inhaled hislainine. These results suggest that inhalation of procalerol has an inhibitory effect on antigen-induced TXA2 production as well as a protective effect against bronchoconstriction induced by bronchoactive agents.

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