Rheumatology Unit, Department of Medicine, Hammersmith Hospital, London, U.K.
Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 21, Issue 5, pages 569–572, September 1991
How to Cite
LUNARDI, C., BAMBARA, L. M., BIASI, D., CORTINA, P., PEROLI, P., NICOLIS, F., FAVARI, F. and PACOR, M. L. (1991), Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance. Clinical & Experimental Allergy, 21: 569–572. doi: 10.1111/j.1365-2222.1991.tb00848.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 31 October 1990; revised 20 March 1991; accepted 12 April 1991.
Twenty patients with irritable bowel syndrome due to food intolerance were randomized to either oral sodium cromoglycate or placebo in a double-blind cross-over trial. The study consisted of treatment with either sodium cromoglycate or placebo for 8 weeks, followed by the cross-over treatment for 8 further weeks. Patients were allowed to eat the offending foods during the study. Eighteen patients completed the study. Analysis of patients' diary card scores showed a statistically significant difference in favour of sodium cromoglycate. There was a long carry-over effect in the active-placebo order group. Therefore oral sodium cromoglycate seems to be a useful treatment in patients with irritable bowel syndrome and proven food intolerance.