Both genetic and environmental influences have been implicated in the pathogenesis of atopic disease. A recent report suggested that a major gene providing susceptibility to atopy was transmitted in a pattern consistent with autosomal dominant inheritance and evidence was presented that places the disease locus near the D11S97 marker on human chromosome 11q. In this report, we present three large, highly characterized pedigrees in which atopy is transmitted in a pattern consistent with autosomal dominant inheritance. Genotypes at the D11S97and HLA loci were evaluated using both lod score and sib pair methods of analysis. In these pedigrees, we reject close to moderate linkage (up to 10 cM) of atopy with both D11S97 and HLA.
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