Get access

A double-blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema

Authors


Dr M. T. Glover, Department of Dermatology, The Royal London Hospital, Whitechapel, London E1 1BB, U.K.

Summary

A double-blind controlled trial of hyposensitization with tyrosine-adsorbed Dermatophagoides pteronyssinus vaccine in 24 children with atopic eczema and immediate hypersensitivity to D. pteronyssinus failed to demonstrate superiority over placebo after a standard 8 month course of treatment.

In a second phase, children initially administered active treatment were randomly allocated to continue with active treatment or switched to placebo for a further 6 months. The clinical scores suggest that prolonged hyposensitization may be more effective than placebo but the numbers were too small to permit confident conclusions. A dramatic placebo effect may have served to conceal any additional therapeutic effect from active treatment.

Get access to the full text of this article

Ancillary