Specificity mapping of patients IgE response towards the tree pollen major allergens Aln g I, Bet v I and Cor a I
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 22, Issue 3, pages 391–399, March 1992
How to Cite
IPSEN, H., WIHL, J.-Å., PETERSEN, B. N. and LØWENSTEIN, H. (1992), Specificity mapping of patients IgE response towards the tree pollen major allergens Aln g I, Bet v I and Cor a I. Clinical & Experimental Allergy, 22: 391–399. doi: 10.1111/j.1365-2222.1992.tb03101.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 16 May 1991; revised 21 October 1991; accepted 25 October 1991.
The specificity pattern of IgE from non-treated tree pollen allergic patients (n= 38) were evaluated by solid phase absorption of serum samples followed by CRIE on alder, birch and hazel CIE precipitation profiles. The majority of the serum samples seemed to contain IgE antibodies with the following characteristics: specific towards Bet v I alone and common between Aln g I, Bet v I and/or Cor a I, ‘II’. The IgE specificity profiles observed for 95% of the sera tested are compatible with birch pollen allergens being the only sensitizing allergens, indicating that the patients react to allergens from other tree pollens of the Fagales order due to IgE cross-reaction with the major allergens of birch and alder and/or hazel pollens.