Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronical headaches
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 23, Issue 12, pages 982–985, December 1993
How to Cite
WANTKE, F., GÖTZ, M. and JARISCH, R. (1993), Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronical headaches. Clinical & Experimental Allergy, 23: 982–985. doi: 10.1111/j.1365-2222.1993.tb00287.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 3 December 1992; revised 16 June 1993; accepted 1 July 1993.
Histamine-induced food intolerance is not IgE-mediated. Skin-prick testing and specific IgE to food allergens are typically negative. Food rich in histamine or red wine may cause allergy-like symptoms such as sneezing, flush, skin itching, diarrhoea and even shortness of breath. The suspected reason is a diminished histamine degradation based on a deficiency of diamine oxidase. As diamine oxidase cannot be supplemented, a histamine-free diet was implemented to reduce histamine intake. Forty-five patients with a history of suffering from intolerance to food or wine (n=17) and chronic headache (n= 28) were put on the diet over months to years. Fish, cheese, hard cured sausages, pickled cabbage and alcoholic beverages had to be avoided. Complaint intensity and drug-use per week prior to and 4 weeks after a histamine-free diet were compared. After 4 weeks on the diet 33/45 patients improved considerably (p < 0.01), eight of them had total remission. In 12/45 patients, however, no changes in symptoms were observed. Symptoms of food or wine intolerance significantly decreased (P < 0.02; treatment of choice), headaches decreased in frequency (P < 0.001), duration and intensity. After eating histamine-rich food symptoms were reproducible and could be eliminated by anti-histamines in most patients. These data indicate the role of histamine in food and wine intolerance and that histamine-rich food causes a worsening of symptoms in patients suffering from chronic headaches. Results obtained support the hypothesis of a deficiency of diamine oxidase in patients with intolerance to food or wine.