Clinical & Experimental Allergy

Immunogenicity of a so-called hypoallergenic formula in at-risk babies: two case reports

Authors

  • L. BUSINCO,

    Corresponding author
    1. Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy
      L. Businco, Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy.
    Search for more papers by this author
  • P. LUCENTI,

    1. Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy
    Search for more papers by this author
  • G. ARCESE,

    1. Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy
    Search for more papers by this author
  • G. ZIRUOLO,

    1. Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy
    Search for more papers by this author
  • A. CANTANI

    1. Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy
    Search for more papers by this author

L. Businco, Department of Paediatries, Allergy and Clinical Immunology Division, University of Rome ‘La Sapienza’, Rome, Italy.

Summary

The clinical and immunologic findings of two breast-fed babies who experienced anaphylaxis after a feeding with a partially whey hydrolysate formula (PWHF) are reported. Sensitization to this formula seems to have occurred in the first days of life in the Maternity Hospital where the babies were fed the same formula. These two case reports suggest that PWHF may be immunogenic in the IgE system. This data is in agreement with previous studies which showed intact fragments of cow's milk (CM) proteins in PWHF.

Ancillary