Crossreactivity between Dermatophagoides siboney and other house dust mite allergens in sensitized asthmatic patients
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 25, Issue 10, pages 929–934, October 1995
How to Cite
FERRÁNDIZ, R., CASAS, R., DREBORG, S., EINARSSON, R. and FERNÁNDEZ, B. (1995), Crossreactivity between Dermatophagoides siboney and other house dust mite allergens in sensitized asthmatic patients. Clinical & Experimental Allergy, 25: 929–934. doi: 10.1111/j.1365-2222.1995.tb00394.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted U October 1994; revised 9 February 1995; accepted 10 March 1995.
- Dermatophagoides siboney;
- Dermatophagoides pteranyssinus;
- Dermato-phugoides farinae;
- Blomia tropicalis;
- storage mites;
Background The role of Pyroglyphid mites in IgE-mediated serisitizalion has been well eslahlished. Although mites belonging to the genus Dermatophagoidess dominate in the acarofauna of domestic dust. non-pyroglyphid mites might also be of clinical importance. In Cuba, Dermatophagoides siboney is found in dust coexisting with D. pteronyssiuus and Blomia tropicalis. Dermatophagoides forinae is not found. Storage mites, such as Acorus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae might also be present.
Objective The aim of this study was to investigate the allergenic relationships among the mites present in the environment of allergic patients in Cuba.
Methods The crossreactivialty between an extract of D. siboney and the above mentioned six mites was studied by specific IgE inhibition, using sera of mite-sensitive patients after incubation with serial dilutions of D. sibaney.
Results The inhibitory effect of D. sidiney extract was more pronounced against D. farinae. 91%, than against D. pyteronyssinus, 62%. Specific IgE to B. tropicali, A. siro, L. destructor and T. putrescentiae were inhibited to a much lesser extent, i.e. between 47 and 58%. The correlation between IgE to D. siboney and IgE to D. pteronyssinus and D. farinae was of 0.92 and 0.90. respectively. A weaker correlation was found between D. siboney and L. destructor (0.7), A. siro (0.67), B. tropicalis (0.54) and T. putrescentiae (0.51).
Conclusion Thus. D. siboney seems to be most closely related to D. farinae.