Anaphylactic reaction to lychee fruit: evidence for sensitization to profilin
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 25, Issue 10, pages 1018–1023, October 1995
How to Cite
FÄR, J., WÜTHRICH, B. and VIETHS, S. (1995), Anaphylactic reaction to lychee fruit: evidence for sensitization to profilin. Clinical & Experimental Allergy, 25: 1018–1023. doi: 10.1111/j.1365-2222.1995.tb00405.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 15 December; revised 7 April 1995; accepted 28 April 1995.
- lychee fruit;
- skin-prick tests;
Background and Objective Due to the increasing popularity of exotic fruits in the Western diet, allergologists are confronted with allergic reactions to substances in these plants. The present report describes an anaphylactic reaction after the consumption of lychee fruit (Litchi sinensis). The atopic patient also suffers from rhinoconjunctivitis due to a sensitization against pollen of the Compositae family as well as from dyspnoea after eating sunflower seeds. Our goals were to determine crossreactivity between antibodies against lychee fruit and other plants and to characterize the allergen.
Methods and results Specific IgE against lychee fruits were detected by an EAST assay. The allergen was characterized by immunoblot, immunoblot inhibition and KAST inhibition assays. Broad crossreactivity between lychee fruit and other plants was found and profilin identified as the protein responsible for the patient's complex allergy syndrome.
Conclusion Lychee fruit contains a significant amount of profilin. Consumption of this exotic fruit can cause severe anaphylactic reactions in patients being sensitized against the plant pan-allergen profilin.