Clinical & Experimental Allergy

Immunoglobulin E in acute phase response to surgical stress

Authors

  • A. SZCZEKLIK,

    Corresponding author
    1. Department of Medicine, Jagiellonian University School of Medicine. Cracow, Poland
      Professor A Szezeklik, Jagiellonian University School of Medicine, Department of Medicine Skawinska Street 8, 31–066 Cracow, Poland.
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  • J. JAWIEN

    1. Department of Medicine, Jagiellonian University School of Medicine. Cracow, Poland
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Professor A Szezeklik, Jagiellonian University School of Medicine, Department of Medicine Skawinska Street 8, 31–066 Cracow, Poland.

Summary

Background A few years ago we reported that acute myocardial infarction is associated with a distinct, transient rise in serum imtnunoglobulin (Ig)E.

Objective We wondered whether this response is specific only for myocardial infarction or whether it reflects a more generalized phenomenon, precipitated by tissue injury.

Methods We carried out a large prospective study on 149 patients undergoing various surgical procedures. These were the patients undergoing coronary artery bypass surgery, who did (n=39) or did not (n=42) develop perioperative myocardial infarction, patients subjected to various thoracic operations (n= 33), eholecystectotny (n = 17) or repair of the inguitial hernia (n=18). Thirty healthy volunteers fortned the control group.

Results In all groups studied, except the control group, serum IgE levels began to rise shortly after the operation, reached a peak by the fifth postoperative day. and then gradually declined. This was in striking contrast to serurn imnunoglobulin G which soon alter the operation became markedly) depressed, and took more than a week to return to preoperative values. Specific IgE. against common aeroallergens, measured in a subgroup of patients with initially high total serum IgE, showed no uniform pattern of change.

Conclusion Surgical operations are accompanied by a characteristic, transient rise in serum IgE concentration. Immunoglobulin E might be involved in acute phase response to tissue injury.

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