Cytokine production in children outgrowing hen egg allergy


Takeshi Noma MD. Department of Pediatrics Kitasato University School of Medicine. I-I5-I Kitasato, Sagamihara, Kanagawa, 228, Japan.


Background Approximately 40 to 80% of egg-allergic children outgrow egg allergy after 2 to 5 years.

Objective and methods To detail the immunologic mechanisms involved in the development of tolerance to egg proteins, the bahince between interleukin 4 (IL4) and interferon-γ (IFN-γ) synthesis in patients with active atopic dermatitis allergic to hen egg and in those outgrowing hen egg allergy was evaluated.

Results A marked increase in IL4 and a decrease in IFN-γ synthesis by peripheral blood lymphocytes following ovalbumin (OVA) specific in vitro stimulation was observed in active atopic dermatitis. In contrast, OVA-induced IL4 synthesis in patients in remission was comparable to that in normal individuals. An intriguing finding was higher production of IFN-γ by lymphocytes from ovalbumin-inscnsitive patients in remission as compared to normal individuals following antigen stimulation. although cell proliferation in OVA-stimulated lymphocytes was reduced in patients during remission.

Conclusion OVA antigen may be capable of inducing a population of Thl-type cells to produce cytokines such as IFN-γ, resulting in suppression of Th2-type responses, i.e. IL4 secretion. We speculate that the changes in the balance of relevant antigen-induced cytokine synthesis seen in such patients may be causally associated with the improvement in their clinical status.