Clinical & Experimental Allergy

Buckwheat flour hypersensitivity: an occupational asthma in a noodle maker

Authors

  • H.-S. PARK,

    Corresponding author
    1. Department of Allergy and Clinical Immunology, Ajou University, School of Medicine, Suwon, Korea
      Dr H.-S. Park, Department of Allergy and Clinical Immunology. Ajou University Hospital. Paldal-gu Wonchon-dong San 5, Suwon, 442–749. Korea.
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  • D.-H. NAHM

    1. Department of Allergy and Clinical Immunology, Ajou University, School of Medicine, Suwon, Korea
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Dr H.-S. Park, Department of Allergy and Clinical Immunology. Ajou University Hospital. Paldal-gu Wonchon-dong San 5, Suwon, 442–749. Korea.

Summary

Background There have been very few reports of occupationai allergies caused by inhalation of buckwheat flour. In this paper, we present a case of occupational asthma and rhinitis caused by buckwheat flour inhalation.

Methods and results The patient had strong positive responses to grass and ragweed poiiens as well. The bronchoprovocation test showed early asthmatic response to buckwheat flour extracts. Serum specific IgE antibody to buckwheat flour was detected by enzyme-linked immunosorbent assay (ELISA). In order to further identify the allergenic component of the extracts, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and electroblotting studies were performed. Eight IgE binding components (9–55 kDa) were detected within the buckwheat flour extracts.

Conclusion These results suggest that inhalation of buckwheat flour can caused IgE mediated bronchoconstriction.

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