Myeloperoxidase and interleukin-8 levels in chronic sinusitis
Article first published online: 27 APR 2006
Clinical & Experimental Allergy
Volume 27, Issue 6, pages 672–675, June 1997
How to Cite
DEMOLY, P., CRAMPETTE, L., MONDAIN, M., ENANDER, I., JONES, I. and BOUSQUET, J. (1997), Myeloperoxidase and interleukin-8 levels in chronic sinusitis. Clinical & Experimental Allergy, 27: 672–675. doi: 10.1111/j.1365-2222.1997.tb01195.x
- Issue published online: 27 APR 2006
- Article first published online: 27 APR 2006
- Submitted 20 July 1996; revised 12 October 1996; accepted 9 November 1996.
- chronic sinusitis;
- sinus lavage
We have recetitly phenotyped inflammation iti tion-infectious allergic and non-allergic chronic maxillary sinusitis using sinus biopsies and lavage fluids. In this first paper, we have concentrated our work on the eosinophil, T cell, mast cell and macrophage infiltrates. However, many unresolved questions remain and particularly the role of neutrophils needed to be addressed. In the present study, we focused on the neutrophilic inflammation: myeloperoxidase (MPO) and interleukin-8 (IL-8) were measured by immunoassays and neutrophils were enumerated by conventional staining in the sinus lavage fluids of 16 patients with chronic sinusitis and six control subjects. Both MPO and IL-8 levels were significantly higher in patients than in controls (P < 0.01 and 0.005, respectively). There was a significant correlation between MPO levels and neutrophil numbers, and between MPO and IL-8 levels in the sinus lavage fluid (P < 0.0001, Spearman rank correlation). The presence of high levels of IL-8 in the lavage fluids of patients suffering from chronic sinusitis, levels which correlate with those of MPO, suggests that this cytokine may activate neutrophils in this chronic disease.