Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease?
Article first published online: 9 DEC 2003
Clinical & Experimental Allergy
Volume 33, Issue 12, pages 1629–1633, December 2003
How to Cite
Salib, R. J. and Howarth, P. H. (2003), Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease?. Clinical & Experimental Allergy, 33: 1629–1633. doi: 10.1111/j.1365-2222.2003.01828.x
- Issue published online: 9 DEC 2003
- Article first published online: 9 DEC 2003
- upper airway;
The traditional viewpoint that inflammation, owing to a genetic T-helper type 2 (Th2)-directed imbalance, is the cause of allergic rhinitis has meant that the potential coexistence of other genetic defects and the relevance of any airway remodelling changes to disease pathogenesis and persistence have received scant attention, and as such remain controversial areas. This is particularly so in view of the limited published work in this field, which has so far reported markedly conflicting findings. This review endeavours to outline what is known about the nature of the remodelling response within the upper airway in allergic rhinitis, in addition to highlighting specific areas where further research is warranted.