Anaphylaxis after hamster bites – identification of a novel allergen
Article first published online: 9 JUL 2004
Clinical & Experimental Allergy
Volume 34, Issue 7, pages 1122–1123, July 2004
How to Cite
Lim, D. L., Chan, R. M. E., Wen, H., Van Bever, H. P. S. and Chua, K. Y. (2004), Anaphylaxis after hamster bites – identification of a novel allergen. Clinical & Experimental Allergy, 34: 1122–1123. doi: 10.1111/j.1365-2222.2004.01992.x
- Issue published online: 9 JUL 2004
- Article first published online: 9 JUL 2004
- Submitted 26 August 2003; revised 13 January 2004; accepted 24 March 2004
- Dermatophagoides pteronyssinus;
- hamster bites;
- Phodopus sungoris;
Background Hamsters are popular household pets and anaphylaxis after their bites have described. However, the putative allergen has not been identified.
Objective This study was conducted to identify the allergen causing dwarf hamster (Phodopus sungoris) bite-induced anaphylaxis.
Methods Two children with hamster bite-induced anaphylaxis were enrolled. They both had negative results to skin testing and specific IgE to hamster epithelium. However, they were both allergic to Dermatophagoides pteronyssinus (Der p). Identification of the putative IgE-binding allergens from the hamster saliva was performed using immunoblot analysis.
Results A specific IgE-binding component at 21 kD in the hamster saliva was identified. ELISA inhibition tests showed partial inhibition with Der p.
Conclusions The putative allergen from the hamster saliva causing dwarf hamster-induced anaphylaxis was identified. Possible cross-reactivity with Der p was demonstrated. Further studies will be needed to identify the exact nature and function of this allergen.