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Antibiotic use in the first year of life and asthma in early childhood

Authors

  • J.C. Celedón,

    1. Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA,
    2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, USA,
    3. Harvard Medical School, Boston, MA, USA,
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  • A. Fuhlbrigge,

    1. Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA,
    2. Harvard Medical School, Boston, MA, USA,
    3. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA,
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  • S. Rifas-Shiman,

    1. Departments of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
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  • S.T. Weiss,

    1. Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA,
    2. Harvard Medical School, Boston, MA, USA,
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  • J.A. Finkelstein

    1. Harvard Medical School, Boston, MA, USA,
    2. Departments of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    3. Department of Pediatrics, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
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Juan C. Celedón, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.
E-mail: juan.celedon@channing.harvard.edu

Summary

Background An association between antibiotic use in early life and asthma in childhood has been reported in five retrospective studies and one longitudinal study.

Objective To examine the relation between the use of oral antibiotics in the first year of life and asthma in early childhood.

Methods Longitudinal follow-up of 4408 children enrolled in a health maintenance organization (HMO) from birth to the age of 5 years.

Results After adjusting for sex and illnesses of the lower respiratory tract (LRIs), we found a significant association between antibiotic use in the first year of life and asthma between the ages of 1 and 2 years (odds ratio (OR) for 1–2 vs. no courses of antibiotics=1.9, 95% confidence interval (CI)=1.3–2.7; OR for 3–4 vs. no courses of antibiotics=1.6, 95% CI=1.1–2.4; OR for at least 5 vs. no courses of antibiotics=2.1, 95% CI=1.5–3.2). After adjustment for sex and LRIs in the first year of life, there was no significant association between antibiotic use in the first year of life and asthma that was initially diagnosed between the ages of 2 and 5 years and that persisted up to the age of 5 years (OR for 1–2 vs. no courses of antibiotics=1.1, 95% CI=0.8–1.4; OR for 3–4 vs. no courses of antibiotics=1.3, 95% CI=0.9–1.8; OR for at least 5 vs. no courses of antibiotics=1.0, 95% CI=0.7–1.4).

Conclusions Our findings do not support the hypothesis that antibiotic use in early life is associated with the subsequent development of asthma in childhood but rather suggest that frequent antibiotic use in early life is more common among asthmatic children.

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