Clinical & Experimental Allergy

Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults

Authors

  • S. Weidinger,

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
    2. Division of Environmental Dermatology and Allergy GSF/TUM, GSF National Research Center for Environment and Health, Neuherberg, Germany and ZAUM Center for Allergy and Environment, Technical University Munich, Munich, Germany
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  • N. Klopp,

    1. Institute of Epidemiology, GSF – National Research Center for Environment and Health, Neuherberg, Munich, Germany,
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  • L. Rümmler,

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
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  • S. Wagenpfeil,

    1. Institute for Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany,
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  • H. J. Baurecht,

    1. Institute for Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany,
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  • A. Gauger,

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
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  • U. Darsow,

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
    2. Division of Environmental Dermatology and Allergy GSF/TUM, GSF National Research Center for Environment and Health, Neuherberg, Germany and ZAUM Center for Allergy and Environment, Technical University Munich, Munich, Germany
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  • T. Jakob,

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
    2. Division of Environmental Dermatology and Allergy GSF/TUM, GSF National Research Center for Environment and Health, Neuherberg, Germany and ZAUM Center for Allergy and Environment, Technical University Munich, Munich, Germany
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  • N. Novak,

    1. Department of Dermatology and Allergy, University of Bonn, Bonn, Germany,
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  • T. Schäfer,

    1. Institute of Social Medicine, Medical University Lübeck, Lübeck, Germany,
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  • J. Heinrich,

    1. Institute of Epidemiology, GSF – National Research Center for Environment and Health, Neuherberg, Munich, Germany,
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  • H. Behrendt,

    1. Division of Environmental Dermatology and Allergy GSF/TUM, GSF National Research Center for Environment and Health, Neuherberg, Germany and ZAUM Center for Allergy and Environment, Technical University Munich, Munich, Germany
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  • H. E. Wichmann,

    1. Institute of Epidemiology, GSF – National Research Center for Environment and Health, Neuherberg, Munich, Germany,
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  • J. Ring,

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
    2. Division of Environmental Dermatology and Allergy GSF/TUM, GSF National Research Center for Environment and Health, Neuherberg, Germany and ZAUM Center for Allergy and Environment, Technical University Munich, Munich, Germany
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  • T. Illig,

    1. Institute of Epidemiology, GSF – National Research Center for Environment and Health, Neuherberg, Munich, Germany,
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  • for the KORA study group

    1. Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany,
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Dr med. Stephan Weidinger, Department of Dermatology and Allergy, Technical University Munich, Biedersteiner St. 29, 80802 Munich, Germany.
E-mail: weidinger@lrz.tum.de

Summary

Background Influences of microbial pathogens are crucial for the maturation of the immune system. Caspase-recruitment domain containing protein 15 (CARD15) is a cytosolic receptor involved in bacterial recognition by antigen-presenting cells. CARD15 polymorphisms have been associated with Crohn's disease. Recently, associations with atopic phenotypes have been reported in children.

Objective Within a large population of German adults (n=1875), we evaluated eight CARD15 polymorphisms for associations with atopic phenotypes.

Methods Subjects were phenotyped by standardized questionnaires and interviews as well as total and allergen-specific IgE measurements. Genotyping was performed using matrix-assisted laser desorption ionization – time of flight mass spectrometry. Haplotypes were estimated using the SAS/Genetics module.

Results Subjects with a T allele at rs1077861 had a decreased risk of developing asthma (odds ratio OR=0.648, P=0.013), whereas the presence of an A allele at rs3135500 was significantly associated with an increased risk (OR=1.374, P=0.023). In addition, a CARD15 haplotype revealed to be protective against the development of asthma (OR=0.326, P=0.003). Subjects with an A allele at position rs5743266 or a T allele at rs2066842 had a significantly decreased risk of developing allergic rhinoconjunctivitis with ORs of 0.820 (P=0.049) and 0.801 (P=0.025). Polymorphism rs2066845 showed a significant association with increased total serum IgE (OR=2.155, P=0.006).

Conclusion Genetic variants of CARD15 that might result in inappropriate immunomodulation are not only associated with autoimmune diseases but also with atopic disorders.

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