1Former address: Department of Epidemiology, The Public Health College, Harbin Medical University, China.
Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population
Article first published online: 20 JAN 2006
Clinical & Experimental Allergy
Volume 36, Issue 2, pages 204–210, February 2006
How to Cite
Bu, L. M., Bradley, M., Söderhäll, C., Wahlgren, C. F., Kockum, I. and Nordenskjöld, M. (2006), Genome-wide linkage analysis of allergic rhinoconjunctivitis in a Swedish population. Clinical & Experimental Allergy, 36: 204–210. doi: 10.1111/j.1365-2222.2006.02397.x
- Issue published online: 20 JAN 2006
- Article first published online: 20 JAN 2006
- Submitted 10 February 2004; revised 18 March 2005; accepted 21 September 2005
- affected sib pairs;
- allergic rhinoconjunctivitis;
- atopic disorders;
- genome-wide linkage analysis
Background Allergic rhinoconjunctivitis is a common complex disorder characterized by itching and irritation in the nose, bouts of sneezing, watery rhinorrhoea, nasal congestion and itchy eyes with tears and swelling. Like other atopic disorders such as allergic asthma and atopic dermatitis, the development involves complex interactions of genes and environmental factors.
Objective The purpose of this study was to identify susceptibility loci for allergic rhinoconjunctivitis.
Methods We conducted a genome-wide linkage analysis using a non-parametric, affected-relative-pair method. The 250 families used were collected originally for an atopic dermatitis linkage study.
Results Three regions showed favour in evidence of linkage to allergic rhinoconjunctivitis: 3q13 (D3S1278: logarithm of odds ratio (LOD)=1.64, P<0.003), 4q34–35 (D4S1652: LOD=1.49, P<0.005) and 18q12 (D18S535: LOD=1.94, P<0.002). In addition, four regions showed weaker evidence in favour of linkage: 6p22–24 (D6S1959: LOD=1.39, P<0.006), 9p11–q12 (D9S1118: LOD=1.15, P<0.02), 9q33.2–34.3 (D9S915: LOD=1.29, P<0.01) and 17q11.2 (D17S1294: LOD=1.13, P<0.02). In single-point analysis, one locus on chromosome 3 close to marker D3S1278 reaches the suggestive level (LOD=2.28, P<6 × 10−4) while one on chromosome 17 close to marker D17S921 almost reaches this level (LOD=2.17, P<8 × 10−4, Table 3).
|Marker||Map position (cM)†||LOD||P-value‡|
|D3S1278||129.73||2.28||<6 × 10−4|
|D17S921||36.12||2.17||<8 × 10−4|
Conclusion Our results support the linkage to allergic rhinoconjunctivitis on 3q13, 6p23–p24 and 9q34.3 shown in previous investigations.