Association of interferon-γ and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan
Article first published online: 4 SEP 2006
Clinical & Experimental Allergy
Volume 36, Issue 9, pages 1147–1152, September 2006
How to Cite
Wang, T.-N., Chu, Y.-T., Chen, W.-Y., Feng, W.-W., Shih, N.-H., Hsiang, C.-H. and Ko, Y.-C. (2006), Association of interferon-γ and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. Clinical & Experimental Allergy, 36: 1147–1152. doi: 10.1111/j.1365-2222.2006.02551.x
- Issue published online: 4 SEP 2006
- Article first published online: 4 SEP 2006
- Submitted 8 November 2005; revised 22 May 2006; accepted 21 June 2006
- IFN regulatory factor 1;
Background Asthma is a multi-factorial disorder caused by complex interactions between genetic and environmental factors. IFN-γ and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma.
Objective This study investigated CA repeats polymorphism of the IFN-γ gene and GT repeats polymorphism of the IRF-1 gene, which may predispose individuals to asthma pathogenesis.
Methods In the present study, we used the transmission/disequilibrium test (TDT) to investigate the relationship between asthma and the IFN-γ and IRF-1 polymorphisms by studying 348 subjects composed of 232 parents and 116 asthmatic children.
Results For global TDT test, IFN-γ CA repeats and IRF-1 GT repeat polymorphisms showed a significant association with asthma in children (P=0.009 and 0.017, respectively). We demonstrated that 13 CA repeats (138 bp) of IFN-γ gene and 11 GT repeats (306 bp) of IRF-1 gene are significantly preferentially transmitted to asthmatic children (T/NT=89/61, χ2=8.43, P<0.005 and T/NT=75/49, χ2=8.18, P<0.005, respectively). The offspring will have an increased risk of asthma when their parents transmit IFN-γ 13 CA repeats (OR=1.83, P=0.009) and IRF1 11 GT repeats (OR=1.88, P=0.007) to them. But we observed that the IFN-γ and IRF-1 polymorphisms are not associated with IgE concentrations.
Conclusion These findings provide strong evidence of which IFN-γ CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan.