Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production

Authors

  • K. D. Yang,

    1. Departments of Pediatrics and Medical Research, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan,
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  • C.-Y. Ou,

    1. Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • T.-Y. Hsu,

    1. Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • J.-C. Chang,

    1. Departments of Pediatrics and Medical Research, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan,
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  • H. Chuang,

    1. Departments of Pediatrics and Medical Research, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan,
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  • C.-A. Liu,

    1. Departments of Pediatrics and Medical Research, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan,
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  • H.-M. Liang,

    1. Department of Obstetrics & Gynecology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • H.-C. Kuo,

    1. The Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kaohsiung, Taiwan
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  • R.-F. Chen,

    1. Departments of Pediatrics and Medical Research, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan,
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  • E.-Y. Huang

    1. The Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kaohsiung, Taiwan
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Correspondence:
Chia-Yu Ou, Department of Gynecology & Obstetrics, Chang Gung Memorial Hospital at Kaohsiung, 123 Ta-Pei Road, Niau-Sung Hsiang, Kaohsiung 833, Taiwan. E-mail: yangkd.yeh@msa.hinet.net

Summary

Background Genetic heritability and maternal atopy have been correlated to antenatal IgE production, but very few studies have studied gene–maternal atopy interaction on antenatal IgE production. This study investigated the interaction of CTLA-4 polymorphism with prenatal factors on the elevation of cord blood IgE (CBIgE).

Methods Pregnant women were antenatally recruited for collection of prenatal environmental factors by a questionnaire. Umbilical cord blood samples were collected for CBIgE detection by fluorescence-linked enzyme assay and CTLA-4 polymorphism measurement by restriction fragment length polymorphism.

Results A total of 1104 pregnant women initially participated in this cohort study, and 898 of them completed cord blood collection. 21.4% of the newborns had elevation of CBIgE (geqslant R: gt-or-equal, slanted0.5 kU/L). The CTLA-4+49A allele (P=0.021), maternal atopy (P<0.001) and gender (P=0.034), but not the CTLA-4+49G allele, −318C allele, −318T allele, parental smoking or paternal atopy, were significantly correlated with the CBIgE elevation in multivariate analysis. A dichotomous analysis of gene–maternal atopy interactions identified maternal atopy and CTLA-4+49A allele had an additive effect on the CBIgE elevation, especially prominent in male newborns; and in the absence of maternal atopy, CTLA-4+49GG genotype had a protective effect on CBIgE elevation in female newborns.

Conclusions Maternal but not paternal atopy has significant impacts on CBIgE elevation depending on gender and CTLA-4+49A/G polymorphism of newborns. Control of maternal atopy and modulation of CTLA-4 expression in the prenatal stage may be a target for the early prevention of perinatal allergy sensitization.

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