1T. Groot Kormelink and M. Thio have equally contributed to this manuscript.
Atopic and non-atopic allergic disorders: current insights into the possible involvement of free immunoglobulin light chains
Article first published online: 25 NOV 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 39, Issue 1, pages 33–42, January 2009
How to Cite
Groot Kormelink, T., Thio, M., Blokhuis, B. R., Nijkamp, F. P. and Redegeld, F. A. (2009), Atopic and non-atopic allergic disorders: current insights into the possible involvement of free immunoglobulin light chains. Clinical & Experimental Allergy, 39: 33–42. doi: 10.1111/j.1365-2222.2008.03135.x
- Issue published online: 6 JAN 2009
- Article first published online: 25 NOV 2008
- Submitted 8 July 2008; revised 9 September 2008; accepted 16 September 2008
- food allergy;
- immunoglobulin free light chain;
Allergic diseases have become a serious global health problem in the developed world. IgE interacting with its high-affinitiy receptor FcɛRI is considered a major contributing factor to most types of allergies, but depending on the type of allergy, however, a subgroup of patients displays common symptoms and yet lack elevated levels of total serum IgE and/or antigen-specific IgE. Novel therapeutic strategies such as anti-IgE therapy may therefore not be applicable to these patients. It is clear, however, that these patients do display activation of mast cells. In several patients suffering from immunological disorders, an increase in free immunoglobulin (IG) light chain levels can be detected. Previously, we have described the capability of free light chains to elicit immediate hypersensitivity responses. In this Opinion article, we will discuss the role of IgE- and non-IgE-mediated mechanisms in allergic disorders and point out a possible role of free IG light chains in the pathogenesis of the non-atopic types of these allergies.