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Fig. S1.Results for simulated data using smar in R (http://www-stat.stanford.edu/~tibs/SAM/). Each panel shows the estimated FDR and false negative rate (FNR) (solid red and green curves) as well as the 10th and 90th percentiles with the sample size of 24 (12 vs. 12). A horizontal line is drawn at 0.05. The quantity on the horizontal axis| number of genes| refers to both the hypothesized number of truly non-null genes, and the number of genes called significant.

Figs S2–S5. Gene networks associated with asthma exacerbation. This network was generated with Ingenuity Pathway Analysis. Gene products are represented as node and biologic relations between two nodes are indicated by a line. Solid and shaded lines indicate direct and indirect interactions, respectively.

Table S1. Asthma exacerbation related genes

Table S2.P-values of random sampling of six AE and six SA samples

Table S3. Normalized expression values (log transformed) in each sample

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Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.