Get access

γ-aminobutyric acid nurtures allergic asthma


Wei-Yang Lu, Sunnybrook Health Sciences Centre, Research Building, S104, 2075 Bayview Avenue, Toronto, ON Canada M4N 3M5.


Asthma often occurs as a result of immune-based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role of γ-aminobutyric acid (GABA) signalling pathway in the airway epithelium of allergic asthma through its ability to stimulate mucus production. This review briefly describes the GABAergic signalling system and its role in the regulation of mucus protein production in bronchial airway epithelial cells.

Get access to the full text of this article