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Figure S1. The age of sensitisation determines the magnitude of allergic airways inflammation to antigen exposure in later life. Mice were sensitised as neonates (within the first 24 h of life) or weanlings (28 days old) to endotoxin low OVA in the absence (shaded bars) or presence (closed bars) of ssRNA. Unlike the model employed in Fig. 2, neonatal mice did not receive a ‘booster’ OVA sensitisation on day 28. Allergen challenge occurred at 6 wk of age and samples collected at 7 wk of age. a and b) Mediastinal lymph node cells were seeded into 96 well plates at 106/well and stimulated with endotoxinlow OVA for 6 days. IL-13 and IFN-g production were measured by ELISA. Shown are the results of one experiment consisting of groups of five animals. Data are mean±s.e.m; *P<0.05.

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