Prospective association between food sensitization and food allergy: results of the LISA birth cohort study
Article first published online: 2 DEC 2009
© 2009 Blackwell Publishing Ltd
Clinical & Experimental Allergy
Volume 40, Issue 3, pages 450–457, March 2010
How to Cite
Schnabel, E., Sausenthaler, S., Schaaf, B., Schäfer, T., Lehmann, I., Behrendt, H., Herbarth, O., Borte, M., Krämer, U., Von Berg, A., Wichmann, H.-E., Heinrich, J. and for the LISA Study Group (2010), Prospective association between food sensitization and food allergy: results of the LISA birth cohort study. Clinical & Experimental Allergy, 40: 450–457. doi: 10.1111/j.1365-2222.2009.03400.x
- Issue published online: 8 FEB 2010
- Article first published online: 2 DEC 2009
- Submitted 19 March 2009; revised 26 August 2009; accepted 23 September 2009
- food allergy;
- food sensitization;
- specific IgE
Background Food allergy is common, especially in childhood, where 6–8% of children are affected. Identification of early and efficient markers for later development of food allergy is very important.
Objective We examined the ability of repeated measurements of food sensitization in early childhood to predict doctor-diagnosed food allergy (DDFA) at the age of 6 years.
Methods The analysis was based on data from a prospective birth cohort study. Information was collected by parental questionnaires, and blood samples were obtained at 2 and 6 years of age. Children with repeated determination of sensitization to food allergens at 2 and 6 years of age were categorized into the sensitization phenotypes: no, early onset, late onset and persistent sensitization. The association between sensitization phenotypes and DDFA was prospectively investigated using multiple logistic regression analyses.
Results Of 3097 children recruited at birth, a complete follow-up of IgE measurements and questionnaires at 1.5, 2 and 6 years were available for 1082 children. Early food allergen sensitization (fx5) was a strong risk for DDFA at 6 years [odds ratio (OR)=4.7; 95% confidence intervals (95% CI) 2.0–11.2] and for a new onset of DDFA at 6 years (OR=4.1; 95% CI 1.5–11.3). Additionally, persistent food allergen sensitization increased the risk of DDFA at 6 years (OR=6.1; 95% CI 2.7–13.7). Early sensitized children with a history of parental atopy showed the highest risk for DDFA at 6 years.
Conclusion Food-sensitized children during the first 2 years of life, especially with a family history of atopy, might be considered as a susceptible subgroup that requires specific attention concerning the development of food allergy-related symptoms.
>Cite this as: E. Schnabel, S. Sausenthaler, B. Schaaf, T. Schäfer, I. Lehmann, H. Behrendt, O. Herbarth, M. Borte, U. Krämer, A. von Berg, H.-E. Wichmann, J. Heinrich, and for the LISA Study Group, Clinical & Experimental Allergy, 2010 (40) 450–457.